Leuzzi Laboratory
2024
Mapping multimodal phenotypes to perturbations in cells and tissue with CRISPRmap.
Gu J, Iyer A, Wesley B, Taglialatela A, Leuzzi G, Hangai S, Decker A, Gu R, Klickstein N, Shuai Y, Jankovic K, Parker-Burns L, Jin Y, Zhang JY, Hong J, Niu X, Costa JA, Pezet MG, Chou J, Snoeck HW, Landau DA, Azizi E, Chan EM, Ciccia A, Gaublomme JT.
Nat Biotechnol. 2024 Oct 7. doi: 10.1038/s41587-024-02386-x. Online ahead of print.PMID: 39375448
Deciphering the impact of genomic variation on function.
IGVF Consortium.
Nature. 2024 Sep;633(8028):47-57. doi: 10.1038/s41586-024-07510-0. Epub 2024 Sep 4.PMID: 39232149 Review.
Mapping variant effects on anti-tumor hallmarks of primary human T cells with base-editing screens.
Walsh ZH*, Shah P*, Kothapalli N, Shah SB, Nikolenyi G, Brodtman DZ, Leuzzi G, Rogava M, Mu M, Ho P, Abuzaid S, Vasan N, AlQuraishi M, Milner JD, Ciccia A, Melms JC, Izar B.
Nat Biotechnol. 2024 May 23. doi: 10.1038/s41587-024-02235-x. Online ahead of print.PMID: 38783148
Leuzzi G, Vasciaveo A, Taglialatela A, Chen X, Firestone TM, Hickman AR, Mao W, Thakar T, Vaitsiankova A, Huang JW, Cuella-Martin R, Hayward SB, Kesner JS, Ghasemzadeh A, Nambiar TS, Ho P, Rialdi A, Hebrard M, Li Y, Gao J, Gopinath S, Adeleke OA, Venters BJ, Drake CG, Baer R, Izar B, Guccione E, Keogh MC, Guerois R, Sun L, Lu C, Califano A, Ciccia A.
Cell. 2024 Feb 15;187(4):861-881.e32. doi: 10.1016/j.cell.2024.01.008. Epub 2024 Jan 31.PMID: 38301646
Highlights: Feeding two birds with one scone: The dual roles of SMARCAL1 in antitumor immunity. Toufektchan, E., and Maciejowski, J. 202). Mol Cell, 85(5): 819-821; SMARCAL1 Favors Tumor Immune Evasion Through Dual Mechanisms. (2024). Cancer Discovery
2023
The DNA Damage Response and Inflammation in Cancer.
Klapp V, Álvarez-Abril B, Leuzzi G, Kroemer G, Ciccia A, Galluzzi L.
Cancer Discov. 2023 Jul 7;13(7):1521-1545. doi: 10.1158/2159-8290.CD-22-1220.PMID: 37026695
2022
Partial loss-of-function mutations in GINS4 lead to NK cell deficiency with neutropenia.
Conte MI, Poli MC, Taglialatela A, Leuzzi G, Chinn IK, Salinas SA, Rey-Jurado E, Olivares N, Veramendi-Espinoza L, Ciccia A, Lupski JR, Aldave Becerra JC, Mace EM, Orange JS.
JCI Insight. 2022 Nov 8;7(21):e154948. doi: 10.1172/jci.insight.154948.PMID: 36345943
Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas.
Li Y*, Goldberg EM*, Chen X*, Xu X, McGuire JT, Leuzzi G, Karagiannis D, Tate T, Farhangdoost N, Horth C, Dai E, Li Z, Zhang Z, Izar B, Que J, Ciccia A, Majewski J, Yoon AJ, Ailles L, Mendelsohn CL, Lu C.
Mol Cell. 2022 Oct 20;82(20):3901-3918.e7. doi: 10.1016/j.molcel.2022.09.007. Epub 2022 Oct 6.PMID: 36206767
2021
Taglialatela A, Leuzzi G, Sannino V, Cuella-Martin R, Huang JW, Wu-Baer F, Baer R, Costanzo V, Ciccia A.
Mol Cell. 2021 Oct 7;81(19):4008-4025.e7. doi: 10.1016/j.molcel.2021.08.016. Epub 2021 Sep 10.PMID: 34508659
Functional interrogation of DNA damage response variants with base editing screens.
Cuella-Martin R, Hayward SB*, Fan X*, Chen X, Huang JW, Taglialatela A, Leuzzi G, Zhao J, Rabadan R, Lu C, Shen Y, Ciccia A.
Cell. 2021 Feb 18;184(4):1081-1097.e19. doi: 10.1016/j.cell.2021.01.041.PMID: 33606978
2020
HATtracting Nucleases to Stalled Forks.
Leuzzi G, Taglialatela A, Ciccia A.
Mol Cell. 2020 Oct 15;80(2):177-180. doi: 10.1016/j.molcel.2020.09.031.PMID: 33065018
Time for remodeling: SNF2-family DNA translocases in replication fork metabolism and human disease.
Joseph SA, Taglialatela A, Leuzzi G, Huang JW, Cuella-Martin R, Ciccia A.
DNA Repair (Amst). 2020 Nov;95:102943. doi: 10.1016/j.dnarep.2020.102943. Epub 2020 Aug 15.PMID: 32971328
Huang JW, Acharya A, Taglialatela A, Nambiar TS, Cuella-Martin R, Leuzzi G, Hayward SB, Joseph SA, Brunette GJ, Anand R, Soni RK, Clark NL, Bernstein KA, Cejka P, Ciccia A.
Nat Commun. 2020 Jun 11;11(1):2948. doi: 10.1038/s41467-020-16718-3.PMID: 32528060
2019
Stimulation of CRISPR-mediated homology-directed repair by an engineered RAD18 variant.
Nambiar TS, Billon P, Diedenhofen G, Hayward SB, Taglialatela A, Cai K, Huang JW, Leuzzi G, Cuella-Martin R, Palacios A, Gupta A, Egli D, Ciccia A.
Nat Commun. 2019 Jul 30;10(1):3395. doi: 10.1038/s41467-019-11105-z.PMID: 31363085
2018
Billing D, Horiguchi M, Wu-Baer F, Taglialatela A, Leuzzi G, Nanez SA, Jiang W, Zha S, Szabolcs M, Lin CS, Ciccia A, Baer R.
Mol Cell. 2018 Oct 4;72(1):127-139.e8. doi: 10.1016/j.molcel.2018.08.016. Epub 2018 Sep 20.PMID: 30244837
CSA and CSB play a role in the response to DNA breaks.
Pascucci B, Fragale A, Marabitti V, Leuzzi G, Calcagnile AS, Parlanti E, Franchitto A, Dogliotti E, D'Errico M.
Oncotarget. 2018 Jan 29;9(14):11581-11591. doi: 10.18632/oncotarget.24342. eCollection 2018 Feb 20.PMID: 29545921
2017
Taglialatela A*, Alvarez S*, Leuzzi G, Sannino V, Ranjha L, Huang JW, Madubata C, Anand R, Levy B, Rabadan R, Cejka P, Costanzo V, Ciccia A.
Mol Cell. 2017 Oct 19;68(2):414-430.e8. doi: 10.1016/j.molcel.2017.09.036.PMID: 29053959
2016
WRNIP1: A new guardian of genome integrity at stalled replication forks.
Leuzzi G, Marabitti V, Pichierri P, Franchitto A.
Mol Cell Oncol. 2016 Aug 3;3(5):e1215777. doi: 10.1080/23723556.2016.1215777. eCollection 2016.PMID: 27857978
Crosstalk between mismatch repair and base excision repair in human gastric cancer.
Simonelli V*, Leuzzi G*, Basile G*, D'Errico M, Fortini P, Franchitto A, Viti V, Brown AR, Parlanti E, Pascucci B, Palli D, Giuliani A, Palombo F, Sobol RW, Dogliotti E.
Oncotarget. 2016 Jun 20;8(49):84827-84840. doi: 10.18632/oncotarget.10185. eCollection 2017 Oct 17.PMID: 29156686
WRNIP1 protects stalled forks from degradation and promotes fork restart after replication stress.
Leuzzi G, Marabitti V, Pichierri P, Franchitto A.
EMBO J. 2016 Jul 1;35(13):1437-51. doi: 10.15252/embj.201593265. Epub 2016 May 30.PMID: 27242363
2014
Basile G*, Leuzzi G*, Pichierri P, Franchitto A.
Nucleic Acids Res. 2014 Nov 10;42(20):12628-39. doi: 10.1093/nar/gku1022. Epub 2014 Oct 28.PMID: 25352544